David Bote hadn’t even been back in the big leagues for a week before more bad injury luck struck the Cubs infielder.

In the 4th inning of Thursday night’s game at Wrigley Field, Bote collided with Nico Hoerner as both players raced for a ground ball.

Hoerner smacked into Bote’s left shoulder — the same shoulder he separated twice last season and the same shoulder he had surgery on in the fall.

Bote initially stayed in the game to finish the rest of the inning but when the top of the 5th rolled around, Andrelton Simmons took over at second base.

The team later announced that Bote had been removed with left shoulder soreness.

“A little sore,” David Ross. “I’m sure it scared him a little bit. Something we want to look at and be careful with. I don’t think there’s any reason that the training staff’s overly concerned. We’ll look at him tomorrow and see how sore he might be. Pretty good collision there between those two.”

Both Bote (the second baseman) and Hoerner (the shortstop) were shifted on the right side of second base on the play and Hoerner admits that played a factor.

“Just an unfortunate play,” Hoerner said. “The shift puts you in some different spots on the field. It takes away outs but it also puts you in places where you have to communicate on groundballs and that’s not really something I’ve honestly done that much.

“That was probably on me. Neither of us said anything but that’s a play where I should have communicated earlier and just said ‘ball’ or something simple. I think it would’ve made a difference.”

The 29-year-old began the season on the 60-day IL as he recovered from the offseason shoulder surgery. He returned to the big-league club last Friday in St. Louis.

Bote singled and scored in the 2nd inning of Thursday night’s game. He is now hitting .286 with a .412 on-base percentage since returning from the IL.